Ghideon Ezaz was born in Asmara, Eritrea, the son of Zere and Mebrat Ezaz. He received his elementary education up to the fifth grade at Michelangelo Buonarotti, an Italian school. Attending such a school made Ghideon bilingual at an early age, in addition to allowing him to discover an affinity for linguistics which enabled him to speak, read, and write fluently in three different languages by the sixth grade. After Ghideon finished his fifth grade year, his family moved to the United States to join their father who had preceded them.
After emigrating, the family settled in Piney Woods, Mississippi, and Ghideon attended McLaurin Attendance Center, a nearby public school. There he dazzled his teachers and fellow students with his quick adjustment and mastery of the English language. For his ninth-grade year, Ghideon transferred to rigorous Jackson Preparatory School an institution known for its high-achieving students and academic environment. There, Ghideon enrolled in the honors program in both science and mathematics. In his junior and senior years he enrolled in AP classes in history, government, science, and math while maintaining a GPA of 4.4 and ranking in the top ten percent of his class of 140. Ghideon is a National Merit and National Achievement scholar in addition to being a member of the Cum Laude Society.
In high school, Ghideon was involved in the Biomedical Club, Mu Alpha Theta and Quiz Bowl. He ran cross-country. In his senior year he was the vice-president of JETS and was one of the organizers of the Physics Olympics. Ghideon also served as the online co-editor for his school newspaper, The Sentry, and helped expand the newspaper to the World Wide Web.
Ghideon’s commitment to the community can be seen in the service projects that he does through the National Honor Society and his church. In addition, as a senior Ghideon was chosen along with nine other people to represent his school in a dialogue on race relations in Jackson with a nearby public school. By conversing with people from various backgrounds he learned and tried to affect different opinions on issues of race in the community.
During the summer of his sophomore year, Ghideon attended a rigorous summer enrichment program at Southern University in Baton Rouge, LA. He spent the summer of his junior year at Iowa State University, where he participated in research on cardiac arrest. That inspired him to study biomedical engineering in college, and then attend medical school in order to go back to his country of origin and provide much-needed medical services.